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Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM50321374
Substrate
n/a
Meas. Tech.
ChEMBL_640283 (CHEMBL1174608)
IC50
1.9±n/a nM
Citation
 Wilson, KJ; Illig, CR; Chen, J; Wall, MJ; Ballentine, SK; DesJarlais, RL; Chen, Y; Schubert, C; Donatelli, R; Petrounia, I; Crysler, CS; Molloy, CJ; Chaikin, MA; Manthey, CL; Player, MR; Tomczuk, BE; Meegalla, SK Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors. Bioorg Med Chem Lett 20:3925-9 (2010) [PubMed]  Article 
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS
Type:
Protein
Mol. Mass.:
107979.48
Organism:
Homo sapiens (Human)
Description:
P07333
Residue:
972
Sequence:
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM50321374
Synonyms:
4-cyano-N-(4-(1,3-dimethyl-2-(methylsulfonylimino)hexahydropyrimidin-5-yl)-2-(4,4-dimethylcyclohex-1-enyl)phenyl)-1H-imidazole-2-carboxamide | CHEMBL1169980
Type:
Small organic molecule
Emp. Form.:
C26H33N7O3S
Mol. Mass.:
523.65
SMILES:
CN1CC(CN(C)C1=NS(C)(=O)=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:32,(-4.16,-42.5,;-4.16,-40.96,;-2.81,-40.2,;-2.82,-38.66,;-4.15,-37.88,;-5.48,-38.65,;-6.81,-37.87,;-5.49,-40.19,;-6.82,-40.95,;-8.15,-40.17,;-8.15,-38.63,;-9.65,-39.76,;-8.93,-41.5,;-1.49,-37.89,;-.16,-38.66,;1.18,-37.89,;1.18,-36.34,;2.51,-35.57,;3.84,-36.33,;3.85,-37.87,;5.17,-35.56,;6.58,-36.19,;7.61,-35.04,;6.83,-33.71,;5.32,-34.04,;7.44,-32.3,;8.06,-30.89,;-.16,-35.58,;-1.49,-36.35,;-.16,-34.05,;1.17,-33.28,;1.17,-31.74,;-.16,-30.97,;-.94,-29.63,;.6,-29.63,;-1.49,-31.74,;-1.49,-33.29,)|
Structure:
Search PDB for entries with ligand similarity: