Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50248926
Substrate
n/a
Meas. Tech.
ChEMBL_812735 (CHEMBL2019953)
Ki
0.098±n/a nM
Citation
 Laurini, E; Col, VD; Mamolo, MG; Zampieri, D; Posocco, P; Fermeglia, M; Vio, L; Pricl, S Homology Model and Docking-Based Virtual Screening for Ligands of the s1 Receptor. ACS Med Chem Lett 2:834-839 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50248926
Synonyms:
3-((1-(4-chlorobenzyl)piperidin-4-yl)methyl)benzo[d]oxazol-2(3H)-one | 3-[[1-(4-Chlorobenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL473783
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O2
Mol. Mass.:
356.846
SMILES:
Clc1ccc(CN2CCC(Cn3c4ccccc4oc3=O)CC2)cc1
Structure:
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