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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50385050
Substrate
n/a
Meas. Tech.
ChEMBL_821477 (CHEMBL2038007)
IC50
>1000±n/a nM
Citation
 Rew, Y; DeGraffenreid, M; He, X; Jaen, JC; McMinn, DL; Sun, D; Tu, H; Ursu, S; Powers, JP Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11ß-HSD1 inhibitors. Bioorg Med Chem Lett 22:3786-90 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50385050
Synonyms:
CHEMBL2035417
Type:
Small organic molecule
Emp. Form.:
C20H22ClF3N2O4S
Mol. Mass.:
478.913
SMILES:
CC(C)N(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cc(NC(C)=O)ccc1Cl
Structure:
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