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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM18351
Substrate
n/a
Meas. Tech.
ChEMBL_878843 (CHEMBL2184151)
IC50
210000±n/a nM
Citation
Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia. J Med Chem 55:10347-62 (2012) [PubMed] Article
More Info.:
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_BOVIN | Glucosylceramidase
Type:
PROTEIN
Mol. Mass.:
59862.93
Organism:
Bos taurus
Description:
ChEMBL_1460504
Residue:
536
Sequence:
MELSSPSREEYPMPRGRVGIMAASLMGLLLLHTVSWVSGARPCSPKSFGYSSVVCVCNGTYCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTIQANRTGTGLLLTLQPDQKFQKVKGFGGAMTDAAALNILALSPAARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRTYTYDDSPDDFQLLNFSLPEEDVKLKIPLIHQALELANRSVSLFASPWTSPTWLKTNGAVNGKGTLKGQAGDLYHKTWARYFVKFLDAYAEHKLRFWAVTAENEPTAGLLTGYPFQCLGFTPEHQRDFIARDLGPILANSTHRDVRLLMLDDQRLLLPRWAQVVLADPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMRYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDIAKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASKKSDLDTVALLRPDGSAVAVVLNRSSKDVPLTIKDPAVGFMETVSPGYSIHTYLWRRQ
Inhibitor
Name:
BDBM18351
Synonyms:
(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 1-Deoxynojirimycin | 1-deoxynojirimycin (DNJ) | CHEMBL307429 | US20230339856, Compound DNJ | US9181184, 1 | dNM
Type:
natural product
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O