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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50060993
Substrate
n/a
Meas. Tech.
ChEMBL_879299 (CHEMBL2208697)
IC50
300000±n/a nM
Citation
 Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem 54:2529-91 (2011) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50060993
Synonyms:
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Fluoro-biphenyl-4-carboxylic acid | CHEMBL106708
Type:
Small organic molecule
Emp. Form.:
C13H9FO2
Mol. Mass.:
216.2078
SMILES:
OC(=O)c1ccc(cc1)-c1ccc(F)cc1
Structure:
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