Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50400844
Substrate
n/a
Meas. Tech.
ChEMBL_879302 (CHEMBL2208700)
IC50
25±n/a nM
Citation
 Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem 54:2529-91 (2011) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50400844
Synonyms:
CHEMBL2205685
Type:
Small organic molecule
Emp. Form.:
C26H20F3N3O4
Mol. Mass.:
495.4499
SMILES:
Oc1c(Oc2ccccc2-c2ccc(CNc3nc(nc4CCCCc34)C(F)(F)F)cc2)c(=O)c1=O
Structure:
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