Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50404104
Substrate
n/a
Meas. Tech.
ChEBML_48837
Ki
16±n/a nM
Citation
 Chou, YL; Davey, DD; Eagen, KA; Griedel, BD; Karanjawala, R; Phillips, GB; Sacchi, KL; Shaw, KJ; Wu, SC; Lentz, D; Liang, AM; Trinh, L; Morrissey, MM; Kochanny, MJ Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors. Bioorg Med Chem Lett 13:507-11 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50404104
Synonyms:
CHEMBL53011
Type:
Small organic molecule
Emp. Form.:
C24H19ClN2O3S
Mol. Mass.:
450.937
SMILES:
COc1ccc(NC(=O)c2cc(C)ccc2NC(=O)c2sc3ccccc3c2Cl)cc1
Structure:
Search PDB for entries with ligand similarity: