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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50086096
Substrate
n/a
Meas. Tech.
ChEMBL_1383 (CHEMBL616455)
Ki
31.62±n/a nM
Citation
 Gaster, LM; Blaney, FE; Davies, S; Duckworth, DM; Ham, P; Jenkins, S; Jennings, AJ; Joiner, GF; King, FD; Mulholland, KR; Wyman, PA; Hagan, JJ; Hatcher, J; Jones, BJ; Middlemiss, DN; Price, GW; Riley, G; Roberts, C; Routledge, C; Selkirk, J; Slade, PD The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J Med Chem 41:1218-35 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50086096
Synonyms:
2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [2,3-Dihydro-1'-methylspiro(benzofuran-3,4'-piperidine)]-amide | CHEMBL15933 | N-(2,3-Dihydro-1'-methylspiro[benzofuran-3,4'-piperidine]-5-yl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenylcarboxamide
Type:
Small organic molecule
Emp. Form.:
C30H30N4O3
Mol. Mass.:
494.5842
SMILES:
CN1CCC2(COc3ccc(NC(=O)c4ccc(cc4)-c4ccc(cc4C)-c4noc(C)n4)cc23)CC1
Structure:
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