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Target
Synaptic vesicle glycoprotein 2A
Ligand
BDBM50422543
Substrate
n/a
Meas. Tech.
ChEMBL_100153 (CHEMBL857182)
IC50
1990±n/a nM
Citation
 Kenda, BM; Matagne, AC; Talaga, PE; Pasau, PM; Differding, E; Lallemand, BI; Frycia, AM; Moureau, FG; Klitgaard, HV; Gillard, MR; Fuks, B; Michel, P Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J Med Chem 47:530-49 (2004) [PubMed]  Article 
Target
Name:
Synaptic vesicle glycoprotein 2A
Synonyms:
SV2A_RAT | Sv2 | Sv2a | Synaptic vesicle protein 2a
Type:
PROTEIN
Mol. Mass.:
82648.76
Organism:
Rattus norvegicus
Description:
ChEMBL_100153
Residue:
742
Sequence:
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
  
Inhibitor
Name:
BDBM50422543
Synonyms:
CHEMBL153264
Type:
Small organic molecule
Emp. Form.:
C20H31ClN2O2
Mol. Mass.:
366.925
SMILES:
CCCCCCCCN(C(CC)C(N)=O)C(=O)Cc1ccc(Cl)cc1
Structure:
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