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Target
Endothelial lipase
Ligand
BDBM50443627
Substrate
n/a
Meas. Tech.
ChEMBL_1279835 (CHEMBL3095694)
IC50
17±n/a nM
Citation
 Abdel-Magid, AF Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders. ACS Med Chem Lett 4:1016-7 (2013) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM50443627
Synonyms:
CHEMBL3092450 | US9216998, 5
Type:
Small organic molecule
Emp. Form.:
C21H20F3NO
Mol. Mass.:
359.3848
SMILES:
COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F
Structure:
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