Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50444409
Substrate
n/a
Meas. Tech.
ChEMBL_1279785 (CHEMBL3095486)
IC50
1700±n/a nM
Citation
Stevens, BD; Litchfield, J; Pfefferkorn, JA; Atkinson, K; Perreault, C; Amor, P; Bahnck, K; Berliner, MA; Calloway, J; Carlo, A; Derksen, DR; Filipski, KJ; Gumkowski, M; Jassal, C; MacDougall, M; Murphy, B; Nkansah, P; Pettersen, J; Rotter, C; Zhang, Y Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia. Bioorg Med Chem Lett 23:6588-92 (2013) [PubMed] Article
More Info.:
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ