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Target
GTP-binding protein Rheb
Ligand
BDBM50121958
Substrate
n/a
Meas. Tech.
ChEMBL_1287899 (CHEMBL3112318)
Kd
1500000±n/a nM
Citation
 Schöpel, M; Jockers, KF; Düppe, PM; Autzen, J; Potheraveedu, VN; Ince, S; Yip, KT; Heumann, R; Herrmann, C; Scherkenbeck, J; Stoll, R Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists. J Med Chem 56:9664-72 (2014) [PubMed]  Article 
Target
Name:
GTP-binding protein Rheb
Synonyms:
RHEB | RHEB2 | RHEB_HUMAN | Ras homolog enriched in brain
Type:
PROTEIN
Mol. Mass.:
20495.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108016
Residue:
184
Sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
  
Inhibitor
Name:
BDBM50121958
Synonyms:
4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-biphenol | 4,4'-dioxydiphenyl | CHEMBL76398 | DOD | US9688816, 6 | [1,1'-biphenyl]-4,4'-diol | biphenyl-4,4'-diol | p,p'-biphenol | p,p'-dihydroxybiphenyl
Type:
Small organic molecule
Emp. Form.:
C12H10O2
Mol. Mass.:
186.2066
SMILES:
Oc1ccc(cc1)-c1ccc(O)cc1
Structure:
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