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Target
Proteasome subunit beta type-5
Ligand
BDBM50007726
Substrate
n/a
Meas. Tech.
ChEMBL_1334922 (CHEMBL3239238)
Ki
7550±n/a nM
Citation
 Scarbaci, K; Troiano, V; Micale, N; Ettari, R; Tamborini, L; Di Giovanni, C; Cerchia, C; Grasso, S; Novellino, E; Schirmeister, T; Lavecchia, A; Zappalą, M Identification of a new series of amides as non-covalent proteasome inhibitors. Eur J Med Chem 76:1-9 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50007726
Synonyms:
CHEMBL3233455
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2
Mol. Mass.:
286.3688
SMILES:
O=C(Cn1ccccc1=O)NC12CC3CC(CC(C3)C1)C2 |THB:10:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17|
Structure:
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