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Target
D(2) dopamine receptor
Ligand
BDBM50016447
Substrate
n/a
Meas. Tech.
ChEMBL_1347653 (CHEMBL3270692)
Ki
923±n/a nM
Citation
 Chen, J; Levant, B; Jiang, C; Keck, TM; Newman, AH; Wang, S Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists. J Med Chem 57:4962-8 (2014) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50016447
Synonyms:
CHEMBL3265064
Type:
Small organic molecule
Emp. Form.:
C29H33ClN2O2
Mol. Mass.:
477.038
SMILES:
CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccccc1Cl |r,wU:26.30,9.11,6.6,wD:24.26,(35.58,-43.79,;35.58,-42.25,;34.24,-41.49,;34.23,-39.95,;35.56,-39.17,;36.9,-39.94,;38.23,-39.16,;38.62,-40.64,;39.71,-39.56,;40.1,-38.07,;38.61,-37.68,;41.43,-37.29,;42.77,-38.05,;42.78,-39.59,;44.1,-37.28,;44.08,-35.75,;45.4,-34.97,;46.75,-35.73,;48.07,-34.96,;49.41,-35.71,;49.42,-37.25,;48.09,-38.03,;46.76,-37.27,;45.43,-38.05,;32.89,-39.19,;32.12,-37.86,;31.36,-39.2,;30.02,-39.97,;28.69,-39.21,;27.36,-39.98,;27.36,-41.52,;28.69,-42.29,;30.03,-41.52,;31.37,-42.29,)|
Structure:
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