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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50020072
Substrate
n/a
Meas. Tech.
ChEMBL_1363771 (CHEMBL3294188)
IC50
3100±n/a nM
Citation
 Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett 5:544-9 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50020072
Synonyms:
CHEMBL3287862
Type:
Small organic molecule
Emp. Form.:
C30H32N2O4
Mol. Mass.:
484.5861
SMILES:
CC1COc2cc(ccc2N1C(=O)Nc1ccccc1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:26.29,wD:29.33,(.8,-5.69,;2.34,-5.69,;3.11,-7.02,;4.65,-7.02,;5.42,-5.69,;6.96,-5.69,;7.73,-4.36,;6.96,-3.02,;5.42,-3.02,;4.65,-4.36,;3.11,-4.36,;2.34,-3.02,;3.11,-1.69,;.8,-3.02,;.03,-1.69,;-1.51,-1.69,;-2.28,-.35,;-1.51,.98,;.03,.98,;.8,-.35,;9.27,-4.36,;10.04,-5.69,;11.58,-5.69,;12.35,-4.36,;11.58,-3.02,;10.04,-3.02,;13.89,-4.36,;14.66,-3.02,;16.2,-3.02,;16.97,-4.36,;18.51,-4.36,;19.28,-5.69,;18.51,-7.02,;20.82,-5.69,;16.2,-5.69,;14.66,-5.69,)|
Structure:
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