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Target
Kappa-type opioid receptor
Ligand
BDBM50000296
Substrate
n/a
Meas. Tech.
ChEMBL_1447926 (CHEMBL3379229)
Ki
0.340000±n/a nM
Citation
 Bourgeois, C; Werfel, E; Galla, F; Lehmkuhl, K; Torres-Gómez, H; Schepmann, D; Kögel, B; Christoph, T; Straßburger, W; Englberger, W; Soeberdt, M; Hüwel, S; Galla, HJ; Wünsch, B Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted¿-opioid receptor agonists. J Med Chem 57:6845-60 (2014) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50000296
Synonyms:
CHEMBL441765 | CHEMBL482811 | U-50488H | US11492374, ID 1
Type:
Small organic molecule
Emp. Form.:
C19H26Cl2N2O
Mol. Mass.:
369.329
SMILES:
CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Structure:
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