Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM13558
Substrate
n/a
Meas. Tech.
ChEMBL_1466589 (CHEMBL3407182)
Ki
190±n/a nM
Citation
 Glunz, PW; Cheng, X; Cheney, DL; Weigelt, CA; Wei, A; Luettgen, JM; Wong, PC; Wexler, RR; Priestley, ES Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Bioorg Med Chem Lett 25:2169-73 (2015) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM13558
Synonyms:
2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid | phenylglycine deriv. 6 | phenylglycine derivative 1
Type:
Small organic molecule
Emp. Form.:
C19H23N3O4
Mol. Mass.:
357.4036
SMILES:
CCOc1cc(OCC)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O
Structure:
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