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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50061907
Substrate
n/a
Meas. Tech.
ChEMBL_1468212 (CHEMBL3414281)
IC50
900±n/a nM
Citation
Toledo-Sherman, LM; Prime, ME; Mrzljak, L; Beconi, MG; Beresford, A; Brookfield, FA; Brown, CJ; Cardaun, I; Courtney, SM; Dijkman, U; Hamelin-Flegg, E; Johnson, PD; Kempf, V; Lyons, K; Matthews, K; Mitchell, WL; O'Connell, C; Pena, P; Powell, K; Rassoulpour, A; Reed, L; Reindl, W; Selvaratnam, S; Friley, WW; Weddell, DA; Went, NE; Wheelan, P; Winkler, C; Winkler, D; Wityak, J; Yarnold, CJ; Yates, D; Munoz-Sanjuan, I; Dominguez, C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 58:1159-83 (2015) [PubMed] Article
More Info.:
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_MOUSE | Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase
Type:
PROTEIN
Mol. Mass.:
54550.12
Organism:
Mus musculus
Description:
ChEMBL_109577
Residue:
479
Sequence:
MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
Inhibitor
Name:
BDBM50061907
Synonyms:
(+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(+/-)-m-nicotinylbenzoylalanine] | 2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL23983 | meta-nitrobenzoyl)alanine
Type:
Small organic molecule
Emp. Form.:
C10H10N2O5
Mol. Mass.:
238.1968
SMILES:
NC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O