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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50197289
Substrate
n/a
Meas. Tech.
ChEMBL_1619372 (CHEMBL3861541)
IC50
>1000±n/a nM
Citation
 Xu, Z; Xu, X; O'Laoi, R; Ma, H; Zheng, J; Chen, S; Luo, L; Hu, Z; He, S; Li, J; Zhang, H; Zhang, X Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold. Bioorg Med Chem 24:5861-5872 (2016) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50197289
Synonyms:
CHEMBL3970733
Type:
Small organic molecule
Emp. Form.:
C27H21NO
Mol. Mass.:
375.4617
SMILES:
O=C(NCc1ccc-2c(Cc3ccccc-23)c1)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: