Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM82065
Substrate
n/a
Ki
680±n/a nM
Comments
PDSP_1418
Citation
 Lawler, CP; Prioleau, C; Lewis, MM; Mak, C; Jiang, D; Schetz, JA; Gonzalez, AM; Sibley, DR; Mailman, RB Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology 20:612-27 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46945.51
Organism:
RAT
Description:
5-HT6 HTR6 RAT::P31388
Residue:
436
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
  
Inhibitor
Name:
BDBM82065
Synonyms:
CAS_163839 | NSC_163839 | OPC-4392
Type:
Small organic molecule
Emp. Form.:
C24H29N3O2
Mol. Mass.:
391.506
SMILES:
Cc1cccc(N2CCN(CCCOc3ccc4ccc(=O)[nH]c4c3)CC2)c1C
Structure:
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