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Target
Gamma-aminobutyric acid receptor subunit alpha-3
Ligand
BDBM50000766
Substrate
n/a
Ki
13.9±n/a nM
Comments
PDSP_656
Citation
 Griebel, G; Perrault, G; Simiand, J; Cohen, C; Granger, P; Decobert, M; Françon, D; Avenet, P; Depoortere, H; Tan, S; Oblin, A; Schoemaker, H; Evanno, Y; Sevrin, M; George, P; Scatton, B SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors. J Pharmacol Exp Ther 298:753-68 (2001) [PubMed] 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-3
Synonyms:
GABA A anti-Alpha3 | GABA A receptor alpha-3/beta-2/gamma-2 | GABA receptor alpha-3 subunit | GBRA3_RAT | Gabra-3 | Gabra3 | Gamma-aminobutyric acid receptor subunit alpha-3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55444.88
Organism:
RAT
Description:
GABA A Alpha3Beta2Gamma2 0 RAT::P20236
Residue:
493
Sequence:
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFMAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLALDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
  
Inhibitor
Name:
BDBM50000766
Synonyms:
CHEMBL12 | DIAZEPAM | US9271961, Diazepam
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O
Mol. Mass.:
284.74
SMILES:
CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Structure:
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