Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89061
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
1510±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89061
Synonyms:
3-[(4-bromo-3,5-dimethyl-1-pyrazolyl)methyl]benzoic acid [(Z)-[amino-(4-chlorophenyl)methylidene]amino] ester | 3-[(4-bromo-3,5-dimethyl-pyrazol-1-yl)methyl]benzoic acid [(Z)-[amino-(4-chlorophenyl)methylene]amino] ester | MLS-0454730.0001 | [(Z)-[amino-(4-chlorophenyl)methylidene]amino] 3-[(4-bromo-3,5-dimethylpyrazol-1-yl)methyl]benzoate | [(Z)-[azanyl-(4-chlorophenyl)methylidene]amino] 3-[(4-bromanyl-3,5-dimethyl-pyrazol-1-yl)methyl]benzoate | cid_9584371
Type:
Small organic molecule
Emp. Form.:
C20H18BrClN4O2
Mol. Mass.:
461.74
SMILES:
Cc1nn(Cc2cccc(c2)C(=O)ON=C(N)c2ccc(Cl)cc2)c(C)c1Br |w:14.14|
Structure:
Search PDB for entries with ligand similarity: