Reaction Details Report a problem with these data
Target
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Ligand
BDBM92459
Substrate
n/a
Meas. Tech.
SPA Assay
pH
7.3±0
Temperature
295.15±0 K
IC50
24000±2700 nM
Citation
 Niu, X; Fan, X; Sun, J; Ting, P; Narula, S; Lundell, D Inhibition of fucosyltransferase VII by gallic acid and its derivatives. Arch Biochem Biophys 425:51-7 (2004) [PubMed]  Article 
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6
Synonyms:
Alpha-(1,3)-fucosyltransferase IV | FCT3A | FUT6 | FUT6_HUMAN | Fucosyltransferase 6 | Fucosyltransferase IV | Fuct IV
Type:
n/a
Mol. Mass.:
41871.43
Organism:
Homo sapiens (Human)
Description:
P51993
Residue:
359
Sequence:
MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVYPNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEESRYQTRGIAAWFT
  
Inhibitor
Name:
BDBM92459
Synonyms:
CHEMBL384759 | GDP | Guanosine Diphosphate
Type:
Small molecule
Emp. Form.:
C10H15N5O11P2
Mol. Mass.:
443.2005
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Structure:
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