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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM93395
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
27.6±0 nM
IC50
59.5±0.0 nM
Citation
 Ivachtchenko, AV; Golovina, ES; Kadieva, MG; Koryakova, AG; Kovalenko, SM; Mitkin, OD; Okun, IM; Ravnyeyko, IM; Tkachenko, SE; Zaremba, OV Solution phase parallel synthesis of substituted 3-phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: selective serotonin 5-HT(6) receptor antagonists. J Comb Chem 12:445-52 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM93395
Synonyms:
PSTQ Analog, 3{1,28}
Type:
Small molecule
Emp. Form.:
C22H23N5O2S
Mol. Mass.:
421.515
SMILES:
CC1CCC(CC1)Nc1nc2c(nnn2c2ccccc12)S(=O)(=O)c1ccccc1 |(-7.58,11.61,;-6.24,10.84,;-4.91,11.61,;-3.58,10.84,;-3.58,9.3,;-4.91,8.53,;-6.24,9.3,;-2.24,8.53,;-2.24,6.99,;-.91,6.22,;-.91,4.62,;.24,3.59,;-.39,2.18,;-1.92,2.34,;-2.24,3.85,;-3.58,4.68,;-4.91,3.91,;-6.24,4.68,;-6.24,6.22,;-4.91,6.99,;-3.58,6.22,;1.74,3.91,;1.43,5.42,;2.13,2.42,;3.23,4.31,;3.63,5.8,;5.12,6.19,;6.21,5.11,;5.81,3.62,;4.32,3.22,)|
Structure:
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