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Target
Beta-lactamase
Ligand
BDBM98862
Substrate
BDBM98856
Meas. Tech.
Spectrophotometric Assay
IC50
1.6±0.0 nM
Citation
Blizzard, TA; Chen, H; Gude, C; Hermes, JD; Imbriglio, J; Kim, S; Wu, JY; Mortko, CJ; Mangion, I; Rivera, N; Ruck, RT; Shevlin, M Beta-lactamase inhibitors US Patent US8487093 Publication Date 7/16/2013
More Info.:
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase (AmpC)
Type:
Enzyme
Mol. Mass.:
43489.98
Organism:
Pseudomonas aeruginosa
Description:
Q3LG62
Residue:
397
Sequence:
MRDTRFPCLCGIAASTLLFATTPAIADEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTVTLAGYALAQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQLFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQAKVPLKR
Inhibitor
Name:
BDBM98862
Synonyms:
US8487093, 8
Type:
Small organic molecule
Emp. Form.:
C14H19N5O6S
Mol. Mass.:
385.396
SMILES:
CN(C)c1cc(NC(=O)[C@@H]2CCC3CN2C(=O)N3OS(O)(=O)=O)ccn1 |r|