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TargetSerine/threonine-protein kinase pim-1
LigandBDBM104222
Substrate/Competitorn/a
Meas. Tech.PIM-1 Enzyme Assay
pH7.4±0
Temperature295.15±0 K
IC50 17.4±0.0 nM
Citation Allen, SCeleste, LLDavis, TGDeLisle, RKGreschuk, JMGross, SDHicken, EJJackson, LJKallan, NCLyssikatos, JPMarmsater, FPMunson, MCPheneger, JRast, BRobinson, JESchlachter, STTopalov, GTWright, ADZhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent US8575145 Publication Date 11/5/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase PIM
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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  Blast E-value cutoff:
BDBM104222
NameBDBM104222
Synonyms:US8575145, 130 | US8575145, 99/100
TypeSmall organic molecule
Emp. Form.C22H22FN5O
Mol. Mass.391.4414
SMILESCc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Structure
n/a