Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114317
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
21542±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114317
Synonyms:
MLS000529721 | N-[(1,2-dimethyl-5-indolyl)methyl]-4-(1-pyrrolidinylsulfonyl)benzamide | N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidin-1-ylsulfonyl-benzamide | N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidin-1-ylsulfonylbenzamide | N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidinosulfonyl-benzamide | SMR000127185 | cid_5101824
Type:
Small organic molecule
Emp. Form.:
C22H25N3O3S
Mol. Mass.:
411.517
SMILES:
Cc1cc2cc(CNC(=O)c3ccc(cc3)S(=O)(=O)N3CCCC3)ccc2n1C
Structure:
Search PDB for entries with ligand similarity: