Reaction Details Report a problem with these data
Target
Group 3 secretory phospholipase A2
Ligand
BDBM114556
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
66837±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID] 
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM114556
Synonyms:
(E)-3-Phenyl-N-[N'-(pyrazine-2-carbonyl)-hydrazinocarbothioyl]-acrylamide | (E)-3-phenyl-N-[(pyrazin-2-ylcarbonylamino)carbamothioyl]prop-2-enamide | (E)-3-phenyl-N-[(pyrazine-2-carbonylamino)carbamothioyl]prop-2-enamide | (E)-3-phenyl-N-[(pyrazinoylamino)thiocarbamoyl]acrylamide | (E)-N-[[[oxo(2-pyrazinyl)methyl]hydrazo]-sulfanylidenemethyl]-3-phenyl-2-propenamide | MLS000769397 | SMR000434131 | cid_1885341
Type:
Small organic molecule
Emp. Form.:
C15H13N5O2S
Mol. Mass.:
327.361
SMILES:
O=C(NC(=S)NNC(=O)c1cnccn1)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: