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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM114637
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
988±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM114637
Synonyms:
7-Methoxy-3-phenyl-2-p-tolyl-3H-9-oxa-1,3-diaza-anthracene-4,10-dione | 8-methoxy-2-(4-methylphenyl)-3-phenyl-chromeno[2,3-d]pyrimidine-4,5-dione | 8-methoxy-2-(4-methylphenyl)-3-phenyl[1]benzopyrano[2,3-d]pyrimidine-4,5-dione | 8-methoxy-2-(4-methylphenyl)-3-phenylchromeno[2,3-d]pyrimidine-4,5-dione | 8-methoxy-3-phenyl-2-(p-tolyl)chromeno[2,3-d]pyrimidine-4,5-quinone | MLS000779865 | SMR000420051 | cid_1872967
Type:
Small organic molecule
Emp. Form.:
C25H18N2O4
Mol. Mass.:
410.4214
SMILES:
COc1ccc2c(c1)oc1nc(-c3ccc(C)cc3)n(-c3ccccc3)c(=O)c1c2=O
Structure:
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