Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM143564
Substrate
n/a
Meas. Tech.
cAMP Assay
Temperature
300.15±n/a K
EC50
4445±n/a nM
Comments
extracted
Citation
 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN Quinazoline derivatives useful as CB-1 inverse agonists US Patent  US9682955 Publication Date 6/20/2017 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM143564
Synonyms:
US9682955, 55
Type:
Small organic molecule
Emp. Form.:
C31H24Cl2F3N3O2
Mol. Mass.:
598.442
SMILES:
OCCOc1nc(NCc2cccc(c2)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: