Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM140548
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
4.3±n/a nM
Comments
extracted
Citation
 Aebi, J; Binggeli, A; Hertel, C; Konkar, AA; Kuehne, H; Kuhn, B; Maerki, HP; Wang, H Biaryl amide derivatives US Patent  US8912221 Publication Date 12/16/2014 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM140548
Synonyms:
US8912221, 21
Type:
Small organic molecule
Emp. Form.:
C21H17ClF5N7O3
Mol. Mass.:
545.85
SMILES:
C[C@@H](NC(=O)C1(COC1)NC(=O)C(F)(F)F)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1 |r|
Structure:
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