Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM141542
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
14600±n/a nM
Citation
 Zoller, G; Petry, S; Muller, G; Heuer, H; Tennagels, N Azole derivatives in the form of lipase and phospholipase inhibitors US Patent  US8921404 Publication Date 12/30/2014 
Target
Name:
Endothelial lipase
Synonyms:
Endothelial lipase (EL) | LIPE_RAT | Lipg
Type:
Enzyme
Mol. Mass.:
55940.01
Organism:
Rattus norvegicus (Rat)
Description:
Q8VBX1
Residue:
493
Sequence:
MRDPVFLLGFWSLYCCFPAGSLTTLRPQGSLRDEHHKPTGVPVTITTKPSVTFNIRTSKDPEHEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQTREKEANVVVVDWLPLAHQLYIDAVSNTRVVGRRVAGMLNWLQEKGEFSLGDVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVMGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDPNRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFRVYHYQLKVHMFSYKNSGDIQPDLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEYLGDLFKIRLTWEGVSSSWYNLWNEFRSYLSQPSSPSRELHIRRIRVKSGETQRKVAFCVQDPMKNSISPGQELWFYKCQNDCRVKN
  
Inhibitor
Name:
BDBM141542
Synonyms:
US8921404, 8
Type:
Small organic molecule
Emp. Form.:
C14H19N3O2
Mol. Mass.:
261.3196
SMILES:
CCCCCCNC(=O)Nc1noc2ccccc12
Structure:
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