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Target
Cyclin-dependent kinase 2
Ligand
BDBM164884
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
pH
7.5±n/a
IC50
913±n/a nM
Comments
extracted
Citation
 Zeitlmann, L; Niestroj, A; Heiser, U Inhibitors of protein kinases US Patent  US9067888 Publication Date 6/30/2015 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM164884
Synonyms:
US9067888, 34
Type:
Small organic molecule
Emp. Form.:
C20H22FN3O3
Mol. Mass.:
371.4054
SMILES:
COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1
Structure:
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