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Target
D-amino-acid oxidase
Ligand
BDBM190386
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
130±n/a nM
Citation
 Farnaby, W; Fieldhouse, C; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D; Hazel, K 5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain US Patent  US9180122 Publication Date 11/10/2015 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM190386
Synonyms:
US9180122, 21
Type:
Small organic molecule
Emp. Form.:
C13H13NO3S
Mol. Mass.:
263.312
SMILES:
COc1ccc(CSc2c[nH]c(=O)c(O)c2)cc1
Structure:
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