Reaction Details
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Report a problem with these dataTarget
Histamine H3 receptor
Ligand
BDBM50434335
Substrate
n/a
Meas. Tech.
Biological Assay
Temperature
298.15±n/a K
Ki
0.02±n/a nM
Comments
extracted
Citation
Cowart, MD; Liu, H; Altenbach, R Mercaptoamidine derivatives and methods of use US Patent US9181275 Publication Date 11/10/2015 More Info.:
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
Inhibitor
Name:
BDBM50434335
Synonyms:
CHEMBL2386729 | US9181275, 3
Type:
Small organic molecule
Emp. Form.:
C26H31N3OS
Mol. Mass.:
433.609
SMILES:
C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=C(C)N2Cc3ccccc3CN=C2S1 |r,c:18,31|
Structure:
