Reaction Details Report a problem with these data
Target
IspB protein
Ligand
BDBM12578
Substrate
n/a
Meas. Tech.
Fluorescent Assay
IC50
2.2e+2± 1e+1 nM
Citation
 Teng, KH; Hsu, ET; Chang, YH; Lin, SW; Liang, PH Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. Biochemistry 55:4366-74 (2016) [PubMed]  Article 
Target
Name:
IspB protein
Synonyms:
Octaprenyl diphosphate synthase (OPPS)
Type:
Protein
Mol. Mass.:
35199.45
Organism:
Escherichia coli (Enterobacteria)
Description:
n/a
Residue:
323
Sequence:
MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQLMNVNDPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDYNADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALIGLAHIAVQRDR
  
Inhibitor
Name:
BDBM12578
Synonyms:
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid
Type:
Small organic molecule
Emp. Form.:
C5H10N2O7P2
Mol. Mass.:
272.0896
SMILES:
OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Structure:
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