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Target
Histone deacetylase 6 [84-835]
Ligand
BDBM198120
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
2.2±0.4 nM
IC50
3.9±0.8 nM
Comments
extracted
Citation
 Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [84-835]
Synonyms:
HDAC6 | HDAC6_HUMAN | KIAA0901 | Tandem CD1-CD2 construct (hCD12) | hCD12
Type:
n/a
Mol. Mass.:
82815.53
Organism:
Homo sapiens (Human)
Description:
Q9UBN7[84-835]
Residue:
752
Sequence:
AGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLR
  
Inhibitor
Name:
BDBM198120
Synonyms:
TSA
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
CC(\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: