Reaction Details Report a problem with these data
Target
Histone deacetylase 6 [60-420]
Ligand
BDBM198120
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
4.8±0.7 nM
IC50
7±1 nM
Comments
extracted
Citation
 Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [60-420]
Synonyms:
Catalytic domain 1 (zCD1) | zCD1
Type:
n/a
Mol. Mass.:
39774.30
Organism:
Danio rerio
Description:
F8W4B7[60-420]
Residue:
360
Sequence:
ATGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGAPCESALKSISKTISDLYPFWKSLQTFE
  
Inhibitor
Name:
BDBM198120
Synonyms:
TSA
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
CC(\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: