Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM225677
Substrate
n/a
Meas. Tech.
ScintillationProximity_Assay
IC50
5.01±n/a nM
Citation
 D3R, DD GSK TrmD D3R 226:0 (2015) [PubMed] 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
TRMD_HAEIN | trmD
Type:
n/a
Mol. Mass.:
27538.79
Organism:
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Description:
n/a
Residue:
246
Sequence:
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
  
Inhibitor
Name:
BDBM225677
Synonyms:
GTC000450A
Type:
Small Organic Molecule
Emp. Form.:
C25H29N3O3
Mol. Mass.:
419.5161
SMILES:
CC(C)(C)c1cccc(c1)C(=O)NCC1(CCCC1)NC(=O)c1cccc2nocc12
Structure:
Search PDB for entries with ligand similarity: