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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM227253
Substrate
n/a
Meas. Tech.
PIM Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.001±n/a nM
Comments
extracted
Citation
 Burch, J; Sun, M; Wang, X; Blackaby, W; Hodges, AJ; Sharpe, A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9328106 Publication Date 5/3/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM227253
Synonyms:
US9328106, 204
Type:
Small organic molecule
Emp. Form.:
C25H25F4N5O3
Mol. Mass.:
519.4913
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cc(cc2F)C2(O)CC2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r,wU:31.35,wD:28.31,33.37,(-5.58,4.02,;-5.58,2.48,;-6.83,1.58,;-6.35,.11,;-4.81,.11,;-4.04,-1.22,;-4.04,-2.76,;-5.38,-3.53,;-2.71,-3.53,;-2.71,-5.07,;-1.38,-5.84,;-.04,-5.07,;1.29,-5.84,;-.04,-3.53,;-1.38,-2.76,;1.29,-2.76,;1.29,-1.22,;-.04,-.45,;2.62,-.45,;3.96,-1.22,;3.96,-2.76,;2.62,-3.53,;2.62,-5.07,;5.29,-.45,;6.06,-1.78,;6.83,-.45,;6.06,.88,;-4.34,1.58,;-3.01,2.35,;-3.01,3.89,;-1.8,4.85,;-.3,4.51,;.47,5.84,;.37,3.12,;1.86,2.72,;-.3,1.73,;-1.8,1.39,)|
Structure:
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