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Target
Genome polyprotein [2420-3010,V2913A]
Ligand
BDBM243456
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR)-Based Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Kd
1500±n/a nM
KOFF
8.40E-04 s-1
KON
5.50E+04 M-1s-1
Comments
extracted
Citation
Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016
More Info.:
Target
Name:
Genome polyprotein [2420-3010,V2913A]
Synonyms:
POLG_HCVJ4 | RNA-directed RNA polymerase (NS5B)(V494A)
Type:
Enzyme
Mol. Mass.:
65755.30
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
V494A
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGAPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR