Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297643
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
>10000±n/a nM
Citation
Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent US10118902 Publication Date 11/6/2018
More Info.:
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Inhibitor
Name:
BDBM297643
Synonyms:
(2-methoxy-ethyl)-{4-[4-(2- methoxy-phenyl)-piperidin-1-yl]- 2-phenyl-quinazolin-6-yl}- methyl-amine | US10118902, Example 145 | US10584103, Example 145
Type:
Small organic molecule
Emp. Form.:
C30H34N4O2
Mol. Mass.:
482.6166
SMILES:
COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)-c1ccccc1