Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM490775
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Binding
Kd
39.0±n/a nM
Citation
 Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent  US10968242 Publication Date 4/6/2021 
Target
Name:
Stimulator of interferon genes protein [H232R]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (H232R) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42215.19
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM490775
Synonyms:
US10968242, Example 3 Peak 2
Type:
Small organic molecule
Emp. Form.:
C20H22FN9O9P2S2
Mol. Mass.:
677.52
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(S)(=O)O[C@@H]3[C@@H](O)[C@H](C[C@H]3n3cnc4c3nc[nH]c4=O)OP(S)(=O)O[C@H]2[C@H]1F |r|
Structure:
Search PDB for entries with ligand similarity: