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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497143
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
16.0±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497143
Synonyms:
US11001561, Compound 118 | US11702392, Compound 118
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2N5O
Mol. Mass.:
456.368
SMILES:
N[C@@H]1c2ccccc2CC11CCN(CC1)c1cc(=O)n(c(N)n1)-c1cccc(Cl)c1Cl |wU:1.0,(4.61,3.48,;4.13,2.02,;2.67,1.54,;1.33,2.31,;,1.54,;;1.33,-.77,;2.67,,;4.13,-.48,;5.04,.77,;5.81,-.56,;7.35,-.56,;8.12,.77,;7.35,2.1,;5.81,2.1,;9.66,.77,;10.43,2.1,;11.97,2.1,;12.74,3.44,;12.74,.77,;11.97,-.56,;12.74,-1.9,;10.43,-.56,;14.28,.77,;15.05,-.56,;16.59,-.56,;17.36,.77,;16.59,2.1,;17.36,3.44,;15.05,2.1,;14.28,3.44,)|
Structure:
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