Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM160865
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
246±n/a nM
Citation
 Brodney, MA; Davoren, JE; Dounay, AB; Efremov, IV; Gray, DL; Green, ME; Henderson, JL; Lee, C; Mente, SR; O''Neil, SV; Rogers, BN; Zhang, L Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US11014909 Publication Date 5/25/2021 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM160865
Synonyms:
US10093655, Example 35 | US11014909, Example 35 | US9107923, 35
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3
Mol. Mass.:
378.4244
SMILES:
Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C |(-.02,3.47,;-.02,1.93,;-1.35,1.15,;-1.35,-.38,;-2.69,-1.15,;-2.69,-2.69,;-1.35,-3.47,;-1.35,-5,;-2.69,-5.78,;-4.02,-5,;-4.02,-3.47,;-5.11,-2.38,;-5.11,-.84,;-6.65,-.84,;-6.65,-2.38,;-.02,-1.15,;1.31,-.38,;1.31,1.15,;2.65,1.93,;2.65,3.47,;1.31,4.23,;3.98,4.23,;3.98,5.78,;5.32,3.47,;5.32,1.93,;6.65,1.15,;3.98,1.15,;3.98,-.38,)|
Structure:
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