Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500000
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500000
Synonyms:
US11021457, Compound 9
Type:
Small organic molecule
Emp. Form.:
C26H21N3O6
Mol. Mass.:
471.4614
SMILES:
O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(NC=C3C(=O)CC(CC3=O)c3ccccc3)ccc12 |(3.97,5.48,;3.2,4.15,;4.11,2.9,;5.65,2.9,;6.42,1.57,;7.96,1.57,;8.73,2.9,;10.27,2.9,;7.96,4.23,;6.42,4.23,;5.65,5.57,;3.2,1.66,;3.97,.32,;1.74,2.13,;.4,1.36,;-.93,2.13,;-2.26,1.36,;-2.26,-.18,;-3.6,-.95,;-4.93,-.18,;-4.93,1.36,;-6.27,-.95,;-6.27,-2.49,;-4.93,-3.26,;-3.6,-2.49,;-2.26,-3.26,;-7.6,-3.26,;-8.93,-2.49,;-10.27,-3.26,;-10.27,-4.8,;-8.93,-5.57,;-7.6,-4.8,;-.93,3.67,;.4,4.44,;1.74,3.67,)|
Structure:
Search PDB for entries with ligand similarity: