Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500043
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<50±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500043
Synonyms:
US11021457, Compound 47
Type:
Small organic molecule
Emp. Form.:
C30H30N4O6
Mol. Mass.:
542.5824
SMILES:
O=C(CCCNC=C1C(=O)CC(CC1=O)c1ccccc1)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |(-2.93,-1.93,;-1.6,-2.69,;-1.6,-4.23,;-2.93,-5,;-4.26,-4.23,;-5.6,-5,;-6.93,-4.23,;-6.93,-2.69,;-8.27,-1.93,;-9.6,-2.69,;-8.27,-.38,;-6.93,.38,;-5.6,-.38,;-5.6,-1.93,;-4.26,-2.69,;-6.93,1.93,;-5.6,2.69,;-5.6,4.23,;-6.93,5,;-8.27,4.23,;-8.27,2.69,;-.26,-1.93,;-.26,-.38,;-1.6,.38,;-1.6,1.93,;-.26,2.69,;1.07,1.93,;2.53,2.4,;3.3,3.73,;3.44,1.15,;2.53,-.09,;1.07,.38,;4.98,1.15,;5.75,2.49,;7.29,2.49,;8.06,1.15,;9.6,1.15,;7.29,-.18,;5.75,-.18,;4.98,-1.51,)|
Structure:
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