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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500086
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500086
Synonyms:
US11021457, Compound 93
Type:
Small organic molecule
Emp. Form.:
C36H40N6O6
Mol. Mass.:
652.7394
SMILES:
O=C(Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)\C=C/CN1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1 |(-.26,-.77,;1.07,-1.54,;2.4,-.77,;2.4,.77,;1.07,1.54,;1.07,3.08,;2.4,3.85,;3.74,3.08,;5.2,3.56,;5.97,4.89,;6.11,2.31,;5.2,1.06,;3.74,1.54,;7.65,2.31,;8.42,3.64,;9.96,3.64,;10.73,2.31,;12.27,2.31,;9.96,.98,;8.42,.98,;7.65,-.36,;1.07,-3.08,;-.26,-3.85,;-1.6,-3.08,;-2.93,-3.85,;-4.26,-3.08,;-5.6,-3.85,;-5.6,-5.39,;-6.93,-6.16,;-8.27,-5.39,;-8.27,-3.85,;-9.6,-3.08,;-9.6,-1.54,;-10.93,-.77,;-12.27,-1.54,;-10.93,.77,;-9.6,1.54,;-8.27,.77,;-8.27,-.77,;-6.93,-1.54,;-9.6,3.08,;-10.93,3.85,;-10.93,5.39,;-9.6,6.16,;-8.27,5.39,;-8.27,3.85,;-4.26,-6.16,;-2.93,-5.39,)|
Structure:
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