Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500108
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500108
Synonyms:
US11021457, Compound 120
Type:
Small organic molecule
Emp. Form.:
C28H25N3O5
Mol. Mass.:
483.5152
SMILES:
O=C1N(Cc2c1cccc2NC=C1C(=O)CC(CC1=O)\C=C\c1ccccc1)C1CCC(=O)NC1=O |(-.7,8.95,;-1.47,7.61,;-.56,6.37,;-1.47,5.12,;-2.93,5.6,;-2.93,7.14,;-4.26,7.91,;-5.6,7.14,;-5.6,5.6,;-4.26,4.83,;-4.26,3.29,;-2.93,2.52,;-2.93,.98,;-4.26,.21,;-5.6,.98,;-4.26,-1.33,;-2.93,-2.1,;-1.6,-1.33,;-1.6,.21,;-.26,.98,;-2.93,-3.64,;-4.26,-4.41,;-4.26,-5.95,;-5.6,-6.72,;-5.6,-8.26,;-4.26,-9.03,;-2.93,-8.26,;-2.93,-6.72,;.98,6.37,;1.75,5.03,;3.29,5.03,;4.06,6.37,;5.6,6.37,;3.29,7.7,;1.75,7.7,;.98,9.03,)|
Structure:
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