Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [139-379,H232R]
Ligand
BDBM501193
Substrate
n/a
Meas. Tech.
STING Human Cell Reporter Assay
EC50
1810±n/a nM
Citation
 Emanuel, S; Richter, M; Connolly, PJ; Edwards, JP; Wang, G; Thatikonda, SK; Beigelman, L; Zhong, M; Bignan, G Cyclic dinucleotides as sting agonists US Patent  US11021511 Publication Date 6/1/2021 
Target
Name:
Stimulator of interferon genes protein [139-379,H232R]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (aa 139-379 H232R) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27090.78
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
241
Sequence:
LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM501193
Synonyms:
US11021511, Compound 1
Type:
Small organic molecule
Emp. Form.:
C21H26N10O13P2
Mol. Mass.:
688.4379
SMILES:
CC1(O)C(OC2COP(O)(=O)OC3C(O)C(COP(O)(=O)OC12)OC3n1cnc2c1nc(N)[nH]c2=O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: